MA 01844是美国旅游签证的有效期哪个地方
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时间：2018-07-26 06:22
Protein knowledgebaseSequence archiveHelp pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects.Sequence clustersProtein sets from fully sequenced genomesAnnotation systemsSystems used to automatically annotate proteins with high accuracy:Supporting dataSelect one of the options below to target your search:You are using a version of browser that may not display all the features of this website. Please consider upgrading . RNA-binding protein EWSEWSR1Homo sapiens (Human)-Annotation score: -Experimental evidence at protein leveliFunctioniMight normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.SitesFeature keyPosition(s)DescriptionActionsGraphical viewLengthSiteiBreakpoint for insertion to form EWSR1-FEV fusion protein2RegionsFeature keyPosition(s)DescriptionActionsGraphical viewLengthZinc fingeriRanBP2-typeManual assertion according to rulesi 32GO - Molecular functioniInferred from physical interactioniInferred from high throughput direct assayiGO - Biological processiKeywordsiMolecular function, , Biological process, Ligand, Enzyme and pathway databasesSIGNORiNames & TaxonomyiProtein namesiRecommended name:RNA-binding protein EWSAlternative name(s):EWS oncogeneEwing sarcoma breakpoint region 1 proteinGene namesiName:Synonyms:EWSOrganismiTaxonomic identifieri
[]Taxonomic lineagei >
Proteomesi Componenti: Chromosome 22 Organism-specific databasesEuPathDBiHGNCi EWSR1MIMi geneneXtProtiSubcellular locationi
Extracellular region or secreted
Plasma membrane
Cytoskeleton
Peroxisome
Golgi apparatus
Mitochondrion
Manual annotation
Automatic computational assertionGraphics by Christian S Source: "Identification and characterization of the nuclear localization/retention signal in the EWS proto-oncoprotein.",
[] [] []Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL, MUTAGENESIS OF ARG-648; ARG-651; ARG-652; ASP-653; ARG-654; PRO-655 AND TYR-656.Nucleus Manual assertion based on experiment ini"Identification and characterization of the nuclear localization/retention signal in the EWS proto-oncoprotein.",
[] [] []Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL, MUTAGENESIS OF ARG-648; ARG-651; ARG-652; ASP-653; ARG-654; PRO-655 AND TYR-656.Other locations Manual assertion based on experiment ini"Identification and characterization of the nuclear localization/retention signal in the EWS proto-oncoprotein.",
[] [] []Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL, MUTAGENESIS OF ARG-648; ARG-651; ARG-652; ASP-653; ARG-654; PRO-655 AND TYR-656.Note: Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation.Keywords - Cellular componenti, , , Pathology & BiotechiInvolvement in diseaseiThe protein represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving EWSR1 are found in patients with Ewing sarcoma. Translocation t(11;22)(q24;q12) with FLI1 (PubMed:1522903, PubMed:). Translocation t(7;22)(p22;q12) with ETV1 (PubMed:7700648). Translocation t(21;22)(q22;q21) with ERG (PubMed:). Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with potential oncogenic activity (PubMed:9121764).Manual assertion based on experiment ini"Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours.", , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM EWS), INVOLVEMENT IN EWS, CHROMOSOMAL TRANSLOCATION WITH FLI."A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.", , , , , , Oncogene 10:95)
[] [] []Cited for: CHROMOSOMAL TRANSLOCATION WITH ETV1."A new member of the ETS family fused to EWS in Ewing tumors.", , , , , ,
[] [] []Cited for: INVOLVEMENT IN EWS, CHROMOSOMAL TRANSLOCATION WITH FEV."A patient with two Ewing's sarcomas with distinct EWS fusion transcripts.", ,
[] [] []Cited for: CHROMOSOMAL TRANSLOCATION WITH ERG, CHROMOSOMAL TRANSLOCATION WITH FLI1, INVOLVEMENT IN EWS.Disease descriptionA highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.A chromosomal aberration involving EWSR1 has been found in extraskeletal myxoid chondrosarcoma. Translocation t(9;22)(q22-31;q11-12) with NR4A3.Manual assertion based on experiment ini"Fusion of the EWS gene to a DNA segment from 9q22-31 in a human myxoid chondrosarcoma.", , , , , , , , ,
[] [] []Cited for: CHROMOSOMAL TRANSLOCATION WITH NR4A3.A chromosomal aberration involving EWSR1 is associated with desmoplastic small round cell tumor (DSRCT). Translocation t(11;22)(p13;q12) with WT1.Manual assertion based on experiment ini"Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumor.", ,
[] [] []Cited for: CHROMOSOMAL TRANSLOCATION WITH WT1.A chromosomal aberration involving EWSR1 is associated with malignant melanoma of soft parts (MMSP). Translocation t(12;22)(q13;q12) with ATF1. Malignant melanoma of soft parts, also known as soft tissue clear cell sarcoma, is a rare tumor developing in tendons and aponeuroses.Manual assertion based on experiment ini"EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts.", , , , , , , ,
[] [] []Cited for: CHROMOSOMAL TRANSLOCATION WITH ATF1.A chromosomal aberration involving EWSR1 is associated with small round cell sarcoma. Translocation t(11;22)(p36.1;q12) with PATZ1.Manual assertion based on experiment ini"A novel zinc finger gene is fused to EWS in small round cell tumor.", , , , , , , , , , ,
[] [] []Cited for: CHROMOSOMAL TRANSLOCATION WITH PATZ1.The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving EWSR1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;22)(q13;q12) with ATF1 generates a chimeric EWSR1/ATF1 protein (PubMed:). Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type (PubMed:).Manual assertion based on experiment ini"Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma.", , , , , , , ,
[] [] []Cited for: CHROMOSOMAL TRANSLOCATION WITH ATF1, INVOLVEMENT IN AFH."EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma.", , , , , ,
[] [] []Cited for: CHROMOSOMAL TRANSLOCATION WITH CREB1, INVOLVEMENT IN AFH.Disease descriptionA distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.EFPS arise due to chromosomal translocations in which EWSR1 is fused to a variety of cellular transcription factors. EFPS are very potent transcriptional activators dependent on the EAD and a C-terminal DNA-binding domain contributed by the fusion partner. The spectrum of malignancies associated with EFPS are thought to arise via EFP-induced transcriptional deregulation, with the tumor phenotype specified by the EWSR1 fusion partner and cell type. Transcriptional repression of the transforming growth factor beta type II receptor (TGF beta RII) is an important target of the EWS-FLI1, EWS-ERG, or EWS-ETV1 oncogene.MutagenesisSitesFeature keyPosition(s)DescriptionActionsGraphical viewLengthSiteiBreakpoint for translocation to form chimeric EWSR1/ATF1 protein1Keywords - DiseaseiOrganism-specific databasesDisGeNETiMalaCardsiMIMi phenotype phenotypeOpenTargetsiOrphaneti Desmoplastic small round cell tumor Ewing sarcoma Extraskeletal Ewing sarcoma Extraskeletal myxoid chondrosarcoma Melanoma of soft partsPharmGKBiPolymorphism and mutation databasesBioMutaiDMDMiPTM / ProcessingiMolecule processingFeature keyPosition(s)DescriptionActionsGraphical viewLengthChainiPRO_RNA-binding protein EWS 656Amino acid modificationsFeature keyPosition(s)DescriptionActionsGraphical viewLengthModified residueiP by PKC1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiN6-acetyllysineManual assertion inferred from sequence similarity toi1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmet alternateManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiOmega-N- alternateManual assertion inferred from combination of experimental and computational evidencei"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", , , , , , , , , , , , , , ,
[] [] []Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT ARG-471; ARG-486 AND ARG-615, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiOmega-N-methylarginineManual assertion inferred from combination of experimental and computational evidencei"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", , , , , , , , , , , , , , ,
[] [] []Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT ARG-471; ARG-486 AND ARG-615, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].1Modified residueiAsymmet by PRMT8Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY., , , , , Submitted (DEC-2008) to UniProtKBCited for: PROTEIN SEQUENCE OF ; ; ;
AND , METHYLATION AT ARG-494 AND ARG-615, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmet alternateManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiOmega-N- alternateManual assertion inferred from sequence similarity toi1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmet by PRMT8Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.1Modified residueiOmega-N- by PRMT8Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmet by PRMT8Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.1Modified residueiOmega-N- by PRMT8Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmet by PRMT8Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.1Modified residueiAsymmet by PRMT8Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.1Modified residueiOmega-N- by PRMT8Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.1Modified residueiAsymmet alternateManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY., , , , , Submitted (DEC-2008) to UniProtKBCited for: PROTEIN SEQUENCE OF ; ; ;
AND , METHYLATION AT ARG-494 AND ARG-615, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiOmega-N- alternateManual assertion inferred from combination of experimental and computational evidencei"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", , , , , , , , , , , , , , ,
[] [] []Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT ARG-471; ARG-486 AND ARG-615, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Post-translational modificationiP calmodulin-binding inhibits phosphorylation of Ser-266.Manual assertion based on experiment ini"The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain.", , ,
[] [] []Cited for: PARTIAL PROTEIN SEQUENCE, PHOSPHORYLATION AT SER-266.Highly methylated on arginine residues. Methylation is mediated by PRMT1 and, at lower level by PRMT8.Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY., , , , , Submitted (DEC-2008) to UniProtKBCited for: PROTEIN SEQUENCE OF ; ; ;
AND , METHYLATION AT ARG-494 AND ARG-615, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.Keywords - PTMi, , Proteomic databasesEPDiMaxQBiPaxDbiPeptideAtlasiPRIDEiProteomicsDBi [] [] [] []PTM databasesiPTMnetiPhosphoSitePlusiSwissPalmiExpressioniTissue specificityiUbiquitous.Gene expression databasesBgeeiCleanExiExpressionAtlasi baseline and differentialGenevisiblei HSOrganism-specific databasesHPAiInteractioniSubunit structureiBinds POLR2C, SF1, calmodulin and RNA. Interacts with PTK2B/FAK2 and TDRD3. Binds calmodulin in the presence, but not in the absence, of calcium ion.Manual assertion based on experiment ini"The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.", ,
[] [] []Cited for: INTERACTION WITH SF1."TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.", , , ,
[] [] []Cited for: INTERACTION WITH TDRD3.Binary interactionsiGO - Molecular functioniInferred from physical interactioniProtein-protein interaction databasesBioGridi, 650 interactorsCORUMiDIPiIntActi, 168 interactorsMINTiSTRINGiStructureiSecondary structure1656Legend: HelixTurnBeta strandPDB Structure known for this areaFeature keyPosition(s)DescriptionActionsGraphical viewLengthBeta strandiManual assertion inferred from combination of experimental and computational evidencei5HelixiManual assertion inferred from combination of experimental and computational evidencei8TurniManual assertion inferred from combination of experimental and computational evidencei3Beta strandiManual assertion inferred from combination of experimental and computational evidencei3Beta strandiManual assertion inferred from combination of experimental and computational evidencei4TurniManual assertion inferred from combination of experimental and computational evidencei3Beta strandiManual assertion inferred from combination of experimental and computational evidencei9HelixiManual assertion inferred from combination of experimental and computational evidencei11Beta strandiManual assertion inferred from combination of experimental and computational evidencei33D structure databasesDisProtiProteinModelPortaliSMRiModBaseiMobiDBiMiscellaneous databasesEvolutionaryTraceiFamily & DomainsiDomains and RepeatsFeature keyPosition(s)DescriptionActionsGraphical viewLengthRepeati19Repeati2 11Repeati37Repeati48Repeati58Repeati69Repeati79Repeati87Repeati99Repeati107Repeati11 19Repeati126Repeati139Repeati14 31Repeati157Repeati167Repeati177Repeati18 11Repeati195Repeati208Repeati215Repeati226Repeati236Repeati246Repeati256Repeati268Repeati277Repeati287Repeati297DomainiIQ 30Repeati30 17Repeati319DomainiRRMManual assertion according to rulesi 87RegionFeature keyPosition(s)DescriptionActionsGraphical viewLengthRegioniEAD (Gln/Pro/Thr-rich) 285Regioni31 X approximate tandem repeats 278MotifFeature keyPosition(s)DescriptionActionsGraphical viewLengthMotifiNuclear localization signalManual assertion based on experiment ini"Identification and characterization of the nuclear localization/retention signal in the EWS proto-oncoprotein.",
[] [] []Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL, MUTAGENESIS OF ARG-648; ARG-651; ARG-652; ASP-653; ARG-654; PRO-655 AND TYR-656. 18Compositional biasFeature keyPosition(s)DescriptionActionsGraphical viewLengthCompositional biasiArg/Gly/Pro-rich 41Compositional biasiArg/Gly/Pro-rich 60Compositional biasiArg/Gly/Pro-rich 82DomainiEWS activation domain (EAD) functions as a potent activation domain in EFPS. EWSR1 binds POLR2C but not POLR2E or POLR2G, whereas the isolated EAD binds POLR2E and POLR2G but not POLR2C. Cis-linked RNA-binding domain (RBD) can strongly and specifically repress trans-activation by the EAD.Sequence similaritiesiBelongs to the .Zinc fingerFeature keyPosition(s)DescriptionActionsGraphical viewLengthZinc fingeriRanBP2-typeManual assertion according to rulesi 32Keywords - Domaini, Phylogenomic databaseseggNOGi Eukaryota LUCAGeneTreeiHOGENOMiHOVERGENiInParanoidiKOiOMAiOrthoDBiPhylomeDBiTreeFamiFamily and domain databasesCDDi RRM_EWS, 1 hitGene3Di, 1 hitInterProi EWS_RRM EWSR1 Nucleotide-bd_a/b_plait_sf RBD_domain_sf RRM_dom TET_fam Znf_RanBP2 Znf_RanBP2_sfPANTHERi PTHR23238, 1 hit PTHR23238:SF3, 1 hitPfami RRM_1, 1 hit zf-RanBP, 1 hitSMARTi RRM, 1 hit ZnF_RBZ, 1 hitSUPFAMi SSF54928, 1 hit SSF90209, 1 hitPROSITEi RRM, 1 hit ZF_RANBP2_1, 1 hit ZF_RANBP2_2, 1 hitSequences (6)iSequence statusi: Complete.This entry describes 6 isoformsi produced by alternative splicing.
(identifier: Q01844-1)
[]This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
50MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQAYGQQS YGTYGQPTDV
100SYTQAQTTAT YGQTAYATSY GQPPTGYTTP TAPQAYSQPV QGYGTGAYDT
150TTATVTTTQA SYAAQSAYGT QPAYPAYGQQ PAATAPTRPQ DGNKPTETSQ
200PQSSTGGYNQ PSLGYGQSNY SYPQVPGSYP MQPVTAPPSY PPTSYSSTQP
250TSYDQSSYSQ QNTYGQPSSY GQQSSYGQQS SYGQQPPTSY PPQTGSYSQA
300PSQYSQQSSS YGQQSSFRQD HPSSMGVYGQ ESGGFSGPGE NRSMSGPDNR
350GRGRGGFDRG GMSRGGRGGG RGGMGSAGER GGFNKPGGPM DEGPDLDLGP
400PVDPDEDSDN SAIYVQGLND SVTLDDLADF FKQCGVVKMN KRTGQPMIHI
450YLDKETGKPK GDATVSYEDP PTAKAAVEWF DGKDFQGSKL KVSLARKKPP
500MNSMRGGLPP REGRGMPPPL RGGPGGPGGP GGPMGRMGGR GGDRGGFPPR
550GPRGSRGNPS GGGNVQHRAG DWQCPNPGCG NQNFAWRTEC NQCKAPKPEG
600FLPPPFPPPG GDRGRGGPGG MRGGRGGLMD RGGPGGMFRG GRGGDRGGFR
650GGRGMDRGGF GGGRRGGPGG PPGPLMEQMG GRRGGRGGPG KMDKGEHRQE RRDRPY
65668,478June 1, 1994 - v1Checksum:i0DA02CEE146720BBBLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: Q01844-2)
[]The sequence of this isoform differs from the canonical sequence as follows:
: Missing.Note: No experimental confirmation available.58361,217Checksum:i1BB290EDBLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: Q01844-3)
[]The sequence of this isoform differs from the canonical sequence as follows:
: Missing.65568,391Checksum:iB539ED1E98C601EDBLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: Q01844-4)
[]The sequence of this isoform differs from the canonical sequence as follows:
: SAGERGGFNKPGGPMDEGPDLDLGPPVDP → LQSESLVYTSILKKYPYSVLSRQHNEKWD
: Missing.Note: No experimental confirmation available.35437,620Checksum:iAE4B8FCDF458390BBLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: Q01844-5)
[]The sequence of this isoform differs from the canonical sequence as follows:
: P → PTVEGTS
: Missing.Note: No experimental confirmation available.66168,966Checksum:i5F84F52FDCD51269BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: Q01844-6)
[]The sequence of this isoform differs from the canonical sequence as follows:
: Missing.Note: No experimental confirmation available.60062,508Checksum:iB3DFFFB0BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutterSequence cautioniThe sequence
differs from that shown. Reason: Erroneous initiation.Experimental InfoFeature keyPosition(s)DescriptionActionsGraphical viewLengthSequence conflictiS → G in
(PubMed:).1Alternative sequenceFeature keyPosition(s)DescriptionActionsGraphical viewLengthAlternative sequenceiVSP_043451P → PTVEGTS in isoform . Manual assertion based on opinion ini"Complete sequencing and characterization of 21,243 full-length human cDNAs.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 6).1Alternative sequenceiVSP_045412Missing
in isoform . Manual assertion based on opinion ini"Complete sequencing and characterization of 21,243 full-length human cDNAs.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 6). 56Alternative sequenceiVSP_005793Missing
in isoform .
73Alternative sequenceiVSP_043452SAGER…PPVDP → LQSESLVYTSILKKYPYSVL SRQHNEKWD in isoform . Manual assertion based on opinion ini"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS EWS; 3 AND 4). 29Alternative sequenceiVSP_043453Missing
in isoform
and isoform . Manual assertion based on opinion ini"A genome annotation-driven approach to cloning the human ORFeome.", , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)."Complete sequencing and characterization of 21,243 full-length human cDNAs.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 6)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS EWS; 3 AND 4).1Alternative sequenceiVSP_043454Missing
in isoform . Manual assertion based on opinion ini"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS EWS; 3 AND 4). 302Sequence databasesSelect the link destinations:EMBLiGenBankiDDBJi mRNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
mRNA Translation:
mRNA Translation:
mRNA Translation: , ,
Genomic DNA Translation: , ,
Genomic DNA Translation: , ,
Genomic DNA Translation: , ,
Genomic DNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
mRNA Translation:
mRNA Translation:
mRNA Translation:
mRNA Translation:
Genomic DNA Translation:
Different initiation. Genomic DNA Translation: CCDSi [] [] [] [] []PIRiRefSeqi,
[]UniGeneiGenome annotation databasesEnsembli; ;
[]GeneIDiKEGGiUCSCi human []Keywords - Coding sequence diversityi, Similar proteinsi751718693687675Q01844-2626602597589584Q01844-4354406358356354Q01844-6627602600600600751718693687675Q01844-2626602597589584Q01844-4270270302270302Q01844-6627602600600600 mRNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
mRNA Translation:
mRNA Translation:
mRNA Translation: , ,
Genomic DNA Translation: , ,
Genomic DNA Translation: , ,
Genomic DNA Translation: , ,
Genomic DNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
mRNA Translation:
mRNA Translation:
mRNA Translation:
mRNA Translation:
Genomic DNA Translation:
Different initiation. Genomic DNA Translation: CCDSi [] [] [] [] []PIRiRefSeqi,
[]UniGenei3D structure databasesSelect the link destinations:PDBeiRCSB PDBiPDBjiPDB entryMethodResolution (?)ChainPositionsPDBsumNMR-A[]DisProtiProteinModelPortaliSMRiModBaseiMobiDBiProtein-protein interaction databasesBioGridi, 650 interactorsCORUMiDIPiIntActi, 168 interactorsMINTiSTRINGiPTM databasesiPTMnetiPhosphoSitePlusiSwissPalmiPolymorphism and mutation databasesBioMutaiDMDMiProteomic databasesEPDiMaxQBiPaxDbiPeptideAtlasiPRIDEiProteomicsDBi [] [] [] []Protocols and materials databasesDNASUiStructural Biology KnowledgebaseGenome annotation databasesEnsembli; ;
[]GeneIDiKEGGiUCSCi human []Organism-specific databasesCTDiDisGeNETiEuPathDBiGeneCardsiHGNCi EWSR1HPAiMalaCardsiMIMi gene phenotype phenotypeneXtProtiOpenTargetsiOrphaneti Desmoplastic small round cell tumor Ewing sarcoma Extraskeletal Ewing sarcoma Extraskeletal myxoid chondrosarcoma Melanoma of soft partsPharmGKBiGenAtlasiPhylogenomic databaseseggNOGi Eukaryota LUCAGeneTreeiHOGENOMiHOVERGENiInParanoidiKOiOMAiOrthoDBiPhylomeDBiTreeFamiEnzyme and pathway databasesSIGNORiMiscellaneous databasesChiTaRSi humanEvolutionaryTraceiGeneWikiiGenomeRNAiiPROiSOURCEiGene expression databasesBgeeiCleanExiExpressionAtlasi baseline and differentialGenevisiblei HSFamily and domain databasesCDDi RRM_EWS, 1 hitGene3Di, 1 hitInterProi EWS_RRM EWSR1 Nucleotide-bd_a/b_plait_sf RBD_domain_sf RRM_dom TET_fam Znf_RanBP2 Znf_RanBP2_sfPANTHERi PTHR23238, 1 hit PTHR23238:SF3, 1 hitPfami RRM_1, 1 hit zf-RanBP, 1 hitSMARTi RRM, 1 hit ZnF_RBZ, 1 hitSUPFAMi SSF54928, 1 hit SSF90209, 1 hitPROSITEi RRM, 1 hit ZF_RANBP2_1, 1 hit ZF_RANBP2_2, 1 hitProtoNeti Q9BWA2Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994Last sequence update: June 1, 1994Last modified: July 18, 2018This is version 210 of the entry and version 1 of the sequence. Entry statusiReviewed (UniProtKB/Swiss-Prot)Annotation programDisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.MiscellaneousiKeywords - Technical termi, , , DocumentsHuman chromosome 22: entries, gene names and cross-references to MIMOnline Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-ProtIndex of Protein Data Bank (PDB) cross-referencesIndex of protein domains and familiesWe'd like to inform you that we have updated our
with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.}
[]Taxonomic lineagei >
Proteomesi Componenti: Chromosome 22 Organism-specific databasesEuPathDBiHGNCi EWSR1MIMi geneneXtProtiSubcellular locationi
Extracellular region or secreted
Plasma membrane
Cytoskeleton
Peroxisome
Golgi apparatus
Mitochondrion
Manual annotation
Automatic computational assertionGraphics by Christian S Source: "Identification and characterization of the nuclear localization/retention signal in the EWS proto-oncoprotein.",
[] [] []Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL, MUTAGENESIS OF ARG-648; ARG-651; ARG-652; ASP-653; ARG-654; PRO-655 AND TYR-656.Nucleus Manual assertion based on experiment ini"Identification and characterization of the nuclear localization/retention signal in the EWS proto-oncoprotein.",
[] [] []Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL, MUTAGENESIS OF ARG-648; ARG-651; ARG-652; ASP-653; ARG-654; PRO-655 AND TYR-656.Other locations Manual assertion based on experiment ini"Identification and characterization of the nuclear localization/retention signal in the EWS proto-oncoprotein.",
[] [] []Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL, MUTAGENESIS OF ARG-648; ARG-651; ARG-652; ASP-653; ARG-654; PRO-655 AND TYR-656.Note: Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation.Keywords - Cellular componenti, , , Pathology & BiotechiInvolvement in diseaseiThe protein represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving EWSR1 are found in patients with Ewing sarcoma. Translocation t(11;22)(q24;q12) with FLI1 (PubMed:1522903, PubMed:). Translocation t(7;22)(p22;q12) with ETV1 (PubMed:7700648). Translocation t(21;22)(q22;q21) with ERG (PubMed:). Translocation t(2;21;22)(q23;q22;q12) that forms a EWSR1-FEV fusion protein with potential oncogenic activity (PubMed:9121764).Manual assertion based on experiment ini"Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours.", , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM EWS), INVOLVEMENT IN EWS, CHROMOSOMAL TRANSLOCATION WITH FLI."A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.", , , , , , Oncogene 10:95)
[] [] []Cited for: CHROMOSOMAL TRANSLOCATION WITH ETV1."A new member of the ETS family fused to EWS in Ewing tumors.", , , , , ,
[] [] []Cited for: INVOLVEMENT IN EWS, CHROMOSOMAL TRANSLOCATION WITH FEV."A patient with two Ewing's sarcomas with distinct EWS fusion transcripts.", ,
[] [] []Cited for: CHROMOSOMAL TRANSLOCATION WITH ERG, CHROMOSOMAL TRANSLOCATION WITH FLI1, INVOLVEMENT IN EWS.Disease descriptionA highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.A chromosomal aberration involving EWSR1 has been found in extraskeletal myxoid chondrosarcoma. Translocation t(9;22)(q22-31;q11-12) with NR4A3.Manual assertion based on experiment ini"Fusion of the EWS gene to a DNA segment from 9q22-31 in a human myxoid chondrosarcoma.", , , , , , , , ,
[] [] []Cited for: CHROMOSOMAL TRANSLOCATION WITH NR4A3.A chromosomal aberration involving EWSR1 is associated with desmoplastic small round cell tumor (DSRCT). Translocation t(11;22)(p13;q12) with WT1.Manual assertion based on experiment ini"Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumor.", ,
[] [] []Cited for: CHROMOSOMAL TRANSLOCATION WITH WT1.A chromosomal aberration involving EWSR1 is associated with malignant melanoma of soft parts (MMSP). Translocation t(12;22)(q13;q12) with ATF1. Malignant melanoma of soft parts, also known as soft tissue clear cell sarcoma, is a rare tumor developing in tendons and aponeuroses.Manual assertion based on experiment ini"EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts.", , , , , , , ,
[] [] []Cited for: CHROMOSOMAL TRANSLOCATION WITH ATF1.A chromosomal aberration involving EWSR1 is associated with small round cell sarcoma. Translocation t(11;22)(p36.1;q12) with PATZ1.Manual assertion based on experiment ini"A novel zinc finger gene is fused to EWS in small round cell tumor.", , , , , , , , , , ,
[] [] []Cited for: CHROMOSOMAL TRANSLOCATION WITH PATZ1.The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving EWSR1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;22)(q13;q12) with ATF1 generates a chimeric EWSR1/ATF1 protein (PubMed:). Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type (PubMed:).Manual assertion based on experiment ini"Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma.", , , , , , , ,
[] [] []Cited for: CHROMOSOMAL TRANSLOCATION WITH ATF1, INVOLVEMENT IN AFH."EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma.", , , , , ,
[] [] []Cited for: CHROMOSOMAL TRANSLOCATION WITH CREB1, INVOLVEMENT IN AFH.Disease descriptionA distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.EFPS arise due to chromosomal translocations in which EWSR1 is fused to a variety of cellular transcription factors. EFPS are very potent transcriptional activators dependent on the EAD and a C-terminal DNA-binding domain contributed by the fusion partner. The spectrum of malignancies associated with EFPS are thought to arise via EFP-induced transcriptional deregulation, with the tumor phenotype specified by the EWSR1 fusion partner and cell type. Transcriptional repression of the transforming growth factor beta type II receptor (TGF beta RII) is an important target of the EWS-FLI1, EWS-ERG, or EWS-ETV1 oncogene.MutagenesisSitesFeature keyPosition(s)DescriptionActionsGraphical viewLengthSiteiBreakpoint for translocation to form chimeric EWSR1/ATF1 protein1Keywords - DiseaseiOrganism-specific databasesDisGeNETiMalaCardsiMIMi phenotype phenotypeOpenTargetsiOrphaneti Desmoplastic small round cell tumor Ewing sarcoma Extraskeletal Ewing sarcoma Extraskeletal myxoid chondrosarcoma Melanoma of soft partsPharmGKBiPolymorphism and mutation databasesBioMutaiDMDMiPTM / ProcessingiMolecule processingFeature keyPosition(s)DescriptionActionsGraphical viewLengthChainiPRO_RNA-binding protein EWS 656Amino acid modificationsFeature keyPosition(s)DescriptionActionsGraphical viewLengthModified residueiP by PKC1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiN6-acetyllysineManual assertion inferred from sequence similarity toi1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmet alternateManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiOmega-N- alternateManual assertion inferred from combination of experimental and computational evidencei"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", , , , , , , , , , , , , , ,
[] [] []Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT ARG-471; ARG-486 AND ARG-615, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiOmega-N-methylarginineManual assertion inferred from combination of experimental and computational evidencei"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", , , , , , , , , , , , , , ,
[] [] []Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT ARG-471; ARG-486 AND ARG-615, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].1Modified residueiAsymmet by PRMT8Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY., , , , , Submitted (DEC-2008) to UniProtKBCited for: PROTEIN SEQUENCE OF ; ; ;
AND , METHYLATION AT ARG-494 AND ARG-615, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmet alternateManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiOmega-N- alternateManual assertion inferred from sequence similarity toi1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmet by PRMT8Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.1Modified residueiOmega-N- by PRMT8Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmet by PRMT8Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.1Modified residueiOmega-N- by PRMT8Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmet by PRMT8Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.1Modified residueiAsymmet by PRMT8Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.1Modified residueiOmega-N- by PRMT8Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.1Modified residueiAsymmet alternateManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY., , , , , Submitted (DEC-2008) to UniProtKBCited for: PROTEIN SEQUENCE OF ; ; ;
AND , METHYLATION AT ARG-494 AND ARG-615, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiOmega-N- alternateManual assertion inferred from combination of experimental and computational evidencei"Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", , , , , , , , , , , , , , ,
[] [] []Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT ARG-471; ARG-486 AND ARG-615, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Modified residueiAsymmetric dimethylarginineManual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY.1Post-translational modificationiP calmodulin-binding inhibits phosphorylation of Ser-266.Manual assertion based on experiment ini"The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain.", , ,
[] [] []Cited for: PARTIAL PROTEIN SEQUENCE, PHOSPHORYLATION AT SER-266.Highly methylated on arginine residues. Methylation is mediated by PRMT1 and, at lower level by PRMT8.Manual assertion based on experiment ini"Exposure on cell surface and extensive arginine methylation of Ewing sarcoma (EWS) protein.", ,
[] [] []Cited for: PROTEIN SEQUENCE OF ; ; ; ; ;
AND , METHYLATION AT ARG-300; ARG-302; ARG-304; ARG-309; ARG-314; ARG-317; ARG-321; ARG-455; ARG-464; ARG-471; ARG-490; ARG-494; ARG-500; ARG-503; ARG-506; ARG-563; ARG-565; ARG-572; ARG-575; ARG-581; ARG-589; ARG-592; ARG-596; ARG-600; ARG-603; ARG-607; ARG-615; ARG-633 AND ARG-636, IDENTIFICATION BY MASS SPECTROMETRY., , , , , Submitted (DEC-2008) to UniProtKBCited for: PROTEIN SEQUENCE OF ; ; ;
AND , METHYLATION AT ARG-494 AND ARG-615, IDENTIFICATION BY MASS SPECTROMETRY."Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.", ,
[] [] []Cited for: METHYLATION AT ARG-490; ARG-572; ARG-596; ARG-603 AND ARG-607.Keywords - PTMi, , Proteomic databasesEPDiMaxQBiPaxDbiPeptideAtlasiPRIDEiProteomicsDBi [] [] [] []PTM databasesiPTMnetiPhosphoSitePlusiSwissPalmiExpressioniTissue specificityiUbiquitous.Gene expression databasesBgeeiCleanExiExpressionAtlasi baseline and differentialGenevisiblei HSOrganism-specific databasesHPAiInteractioniSubunit structureiBinds POLR2C, SF1, calmodulin and RNA. Interacts with PTK2B/FAK2 and TDRD3. Binds calmodulin in the presence, but not in the absence, of calcium ion.Manual assertion based on experiment ini"The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.", ,
[] [] []Cited for: INTERACTION WITH SF1."TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.", , , ,
[] [] []Cited for: INTERACTION WITH TDRD3.Binary interactionsiGO - Molecular functioniInferred from physical interactioniProtein-protein interaction databasesBioGridi, 650 interactorsCORUMiDIPiIntActi, 168 interactorsMINTiSTRINGiStructureiSecondary structure1656Legend: HelixTurnBeta strandPDB Structure known for this areaFeature keyPosition(s)DescriptionActionsGraphical viewLengthBeta strandiManual assertion inferred from combination of experimental and computational evidencei5HelixiManual assertion inferred from combination of experimental and computational evidencei8TurniManual assertion inferred from combination of experimental and computational evidencei3Beta strandiManual assertion inferred from combination of experimental and computational evidencei3Beta strandiManual assertion inferred from combination of experimental and computational evidencei4TurniManual assertion inferred from combination of experimental and computational evidencei3Beta strandiManual assertion inferred from combination of experimental and computational evidencei9HelixiManual assertion inferred from combination of experimental and computational evidencei11Beta strandiManual assertion inferred from combination of experimental and computational evidencei33D structure databasesDisProtiProteinModelPortaliSMRiModBaseiMobiDBiMiscellaneous databasesEvolutionaryTraceiFamily & DomainsiDomains and RepeatsFeature keyPosition(s)DescriptionActionsGraphical viewLengthRepeati19Repeati2 11Repeati37Repeati48Repeati58Repeati69Repeati79Repeati87Repeati99Repeati107Repeati11 19Repeati126Repeati139Repeati14 31Repeati157Repeati167Repeati177Repeati18 11Repeati195Repeati208Repeati215Repeati226Repeati236Repeati246Repeati256Repeati268Repeati277Repeati287Repeati297DomainiIQ 30Repeati30 17Repeati319DomainiRRMManual assertion according to rulesi 87RegionFeature keyPosition(s)DescriptionActionsGraphical viewLengthRegioniEAD (Gln/Pro/Thr-rich) 285Regioni31 X approximate tandem repeats 278MotifFeature keyPosition(s)DescriptionActionsGraphical viewLengthMotifiNuclear localization signalManual assertion based on experiment ini"Identification and characterization of the nuclear localization/retention signal in the EWS proto-oncoprotein.",
[] [] []Cited for: SUBCELLULAR LOCATION, NUCLEAR LOCALIZATION SIGNAL, MUTAGENESIS OF ARG-648; ARG-651; ARG-652; ASP-653; ARG-654; PRO-655 AND TYR-656. 18Compositional biasFeature keyPosition(s)DescriptionActionsGraphical viewLengthCompositional biasiArg/Gly/Pro-rich 41Compositional biasiArg/Gly/Pro-rich 60Compositional biasiArg/Gly/Pro-rich 82DomainiEWS activation domain (EAD) functions as a potent activation domain in EFPS. EWSR1 binds POLR2C but not POLR2E or POLR2G, whereas the isolated EAD binds POLR2E and POLR2G but not POLR2C. Cis-linked RNA-binding domain (RBD) can strongly and specifically repress trans-activation by the EAD.Sequence similaritiesiBelongs to the .Zinc fingerFeature keyPosition(s)DescriptionActionsGraphical viewLengthZinc fingeriRanBP2-typeManual assertion according to rulesi 32Keywords - Domaini, Phylogenomic databaseseggNOGi Eukaryota LUCAGeneTreeiHOGENOMiHOVERGENiInParanoidiKOiOMAiOrthoDBiPhylomeDBiTreeFamiFamily and domain databasesCDDi RRM_EWS, 1 hitGene3Di, 1 hitInterProi EWS_RRM EWSR1 Nucleotide-bd_a/b_plait_sf RBD_domain_sf RRM_dom TET_fam Znf_RanBP2 Znf_RanBP2_sfPANTHERi PTHR23238, 1 hit PTHR23238:SF3, 1 hitPfami RRM_1, 1 hit zf-RanBP, 1 hitSMARTi RRM, 1 hit ZnF_RBZ, 1 hitSUPFAMi SSF54928, 1 hit SSF90209, 1 hitPROSITEi RRM, 1 hit ZF_RANBP2_1, 1 hit ZF_RANBP2_2, 1 hitSequences (6)iSequence statusi: Complete.This entry describes 6 isoformsi produced by alternative splicing.
(identifier: Q01844-1)
[]This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
50MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQAYGQQS YGTYGQPTDV
100SYTQAQTTAT YGQTAYATSY GQPPTGYTTP TAPQAYSQPV QGYGTGAYDT
150TTATVTTTQA SYAAQSAYGT QPAYPAYGQQ PAATAPTRPQ DGNKPTETSQ
200PQSSTGGYNQ PSLGYGQSNY SYPQVPGSYP MQPVTAPPSY PPTSYSSTQP
250TSYDQSSYSQ QNTYGQPSSY GQQSSYGQQS SYGQQPPTSY PPQTGSYSQA
300PSQYSQQSSS YGQQSSFRQD HPSSMGVYGQ ESGGFSGPGE NRSMSGPDNR
350GRGRGGFDRG GMSRGGRGGG RGGMGSAGER GGFNKPGGPM DEGPDLDLGP
400PVDPDEDSDN SAIYVQGLND SVTLDDLADF FKQCGVVKMN KRTGQPMIHI
450YLDKETGKPK GDATVSYEDP PTAKAAVEWF DGKDFQGSKL KVSLARKKPP
500MNSMRGGLPP REGRGMPPPL RGGPGGPGGP GGPMGRMGGR GGDRGGFPPR
550GPRGSRGNPS GGGNVQHRAG DWQCPNPGCG NQNFAWRTEC NQCKAPKPEG
600FLPPPFPPPG GDRGRGGPGG MRGGRGGLMD RGGPGGMFRG GRGGDRGGFR
650GGRGMDRGGF GGGRRGGPGG PPGPLMEQMG GRRGGRGGPG KMDKGEHRQE RRDRPY
65668,478June 1, 1994 - v1Checksum:i0DA02CEE146720BBBLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: Q01844-2)
[]The sequence of this isoform differs from the canonical sequence as follows:
: Missing.Note: No experimental confirmation available.58361,217Checksum:i1BB290EDBLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: Q01844-3)
[]The sequence of this isoform differs from the canonical sequence as follows:
: Missing.65568,391Checksum:iB539ED1E98C601EDBLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: Q01844-4)
[]The sequence of this isoform differs from the canonical sequence as follows:
: SAGERGGFNKPGGPMDEGPDLDLGPPVDP → LQSESLVYTSILKKYPYSVLSRQHNEKWD
: Missing.Note: No experimental confirmation available.35437,620Checksum:iAE4B8FCDF458390BBLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: Q01844-5)
[]The sequence of this isoform differs from the canonical sequence as follows:
: P → PTVEGTS
: Missing.Note: No experimental confirmation available.66168,966Checksum:i5F84F52FDCD51269BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutter (identifier: Q01844-6)
[]The sequence of this isoform differs from the canonical sequence as follows:
: Missing.Note: No experimental confirmation available.60062,508Checksum:iB3DFFFB0BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutterSequence cautioniThe sequence
differs from that shown. Reason: Erroneous initiation.Experimental InfoFeature keyPosition(s)DescriptionActionsGraphical viewLengthSequence conflictiS → G in
(PubMed:).1Alternative sequenceFeature keyPosition(s)DescriptionActionsGraphical viewLengthAlternative sequenceiVSP_043451P → PTVEGTS in isoform . Manual assertion based on opinion ini"Complete sequencing and characterization of 21,243 full-length human cDNAs.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 6).1Alternative sequenceiVSP_045412Missing
in isoform . Manual assertion based on opinion ini"Complete sequencing and characterization of 21,243 full-length human cDNAs.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 6). 56Alternative sequenceiVSP_005793Missing
in isoform .
73Alternative sequenceiVSP_043452SAGER…PPVDP → LQSESLVYTSILKKYPYSVL SRQHNEKWD in isoform . Manual assertion based on opinion ini"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS EWS; 3 AND 4). 29Alternative sequenceiVSP_043453Missing
in isoform
and isoform . Manual assertion based on opinion ini"A genome annotation-driven approach to cloning the human ORFeome.", , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)."Complete sequencing and characterization of 21,243 full-length human cDNAs.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 6)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS EWS; 3 AND 4).1Alternative sequenceiVSP_043454Missing
in isoform . Manual assertion based on opinion ini"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS EWS; 3 AND 4). 302Sequence databasesSelect the link destinations:EMBLiGenBankiDDBJi mRNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
mRNA Translation:
mRNA Translation:
mRNA Translation: , ,
Genomic DNA Translation: , ,
Genomic DNA Translation: , ,
Genomic DNA Translation: , ,
Genomic DNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
mRNA Translation:
mRNA Translation:
mRNA Translation:
mRNA Translation:
Genomic DNA Translation:
Different initiation. Genomic DNA Translation: CCDSi [] [] [] [] []PIRiRefSeqi,
[]UniGeneiGenome annotation databasesEnsembli; ;
[]GeneIDiKEGGiUCSCi human []Keywords - Coding sequence diversityi, Similar proteinsi751718693687675Q01844-2626602597589584Q01844-4354406358356354Q01844-6627602600600600751718693687675Q01844-2626602597589584Q01844-4270270302270302Q01844-6627602600600600 mRNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
mRNA Translation:
mRNA Translation:
mRNA Translation: , ,
Genomic DNA Translation: , ,
Genomic DNA Translation: , ,
Genomic DNA Translation: , ,
Genomic DNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
Genomic DNA Translation:
mRNA Translation:
mRNA Translation:
mRNA Translation:
mRNA Translation:
Genomic DNA Translation:
Different initiation. Genomic DNA Translation: CCDSi [] [] [] [] []PIRiRefSeqi,
[]UniGenei3D structure databasesSelect the link destinations:PDBeiRCSB PDBiPDBjiPDB entryMethodResolution (?)ChainPositionsPDBsumNMR-A[]DisProtiProteinModelPortaliSMRiModBaseiMobiDBiProtein-protein interaction databasesBioGridi, 650 interactorsCORUMiDIPiIntActi, 168 interactorsMINTiSTRINGiPTM databasesiPTMnetiPhosphoSitePlusiSwissPalmiPolymorphism and mutation databasesBioMutaiDMDMiProteomic databasesEPDiMaxQBiPaxDbiPeptideAtlasiPRIDEiProteomicsDBi [] [] [] []Protocols and materials databasesDNASUiStructural Biology KnowledgebaseGenome annotation databasesEnsembli; ;
[]GeneIDiKEGGiUCSCi human []Organism-specific databasesCTDiDisGeNETiEuPathDBiGeneCardsiHGNCi EWSR1HPAiMalaCardsiMIMi gene phenotype phenotypeneXtProtiOpenTargetsiOrphaneti Desmoplastic small round cell tumor Ewing sarcoma Extraskeletal Ewing sarcoma Extraskeletal myxoid chondrosarcoma Melanoma of soft partsPharmGKBiGenAtlasiPhylogenomic databaseseggNOGi Eukaryota LUCAGeneTreeiHOGENOMiHOVERGENiInParanoidiKOiOMAiOrthoDBiPhylomeDBiTreeFamiEnzyme and pathway databasesSIGNORiMiscellaneous databasesChiTaRSi humanEvolutionaryTraceiGeneWikiiGenomeRNAiiPROiSOURCEiGene expression databasesBgeeiCleanExiExpressionAtlasi baseline and differentialGenevisiblei HSFamily and domain databasesCDDi RRM_EWS, 1 hitGene3Di, 1 hitInterProi EWS_RRM EWSR1 Nucleotide-bd_a/b_plait_sf RBD_domain_sf RRM_dom TET_fam Znf_RanBP2 Znf_RanBP2_sfPANTHERi PTHR23238, 1 hit PTHR23238:SF3, 1 hitPfami RRM_1, 1 hit zf-RanBP, 1 hitSMARTi RRM, 1 hit ZnF_RBZ, 1 hitSUPFAMi SSF54928, 1 hit SSF90209, 1 hitPROSITEi RRM, 1 hit ZF_RANBP2_1, 1 hit ZF_RANBP2_2, 1 hitProtoNeti Q9BWA2Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994Last sequence update: June 1, 1994Last modified: July 18, 2018This is version 210 of the entry and version 1 of the sequence. Entry statusiReviewed (UniProtKB/Swiss-Prot)Annotation programDisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.MiscellaneousiKeywords - Technical termi, , , DocumentsHuman chromosome 22: entries, gene names and cross-references to MIMOnline Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-ProtIndex of Protein Data Bank (PDB) cross-referencesIndex of protein domains and familiesWe'd like to inform you that we have updated our
with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.}
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