Volume 57, Issue 12
ARVO Annual Meeting AbstractUnderstanding of inflammatory and non-inflammatory choroidal thickening using laser speckle flowgraphy
Author Affiliations & Notes
Susumu Ishida
Hokkaido Univ Grad Sch of Med, Sapporo, Hokkaido, Japan
Susumu Ishida, None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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Understanding of inflammatory and non-inflammatory choroidal thickening using laser speckle flowgraphy
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Susumu I Understanding of inflammatory and non-inflammatory choroidal thickening using laser speckle flowgraphy. Invest. Ophthalmol. Vis. Sci. ):.
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© 2017 Association for Research in Vision and Ophthalmology.
Presentation Description :
There are distinctly different types of abnormalities showing choroidal thickening with serous retinal detachment: Vogt-Koyanagi-Harada disease (VKH) as an inflammatory disease and central serous chorioretinopathy (CSC) as a non-inflammatory disorder, known as stemming from sympathetic (adrenergic) etiology or systemic corticosteroid use. On indocyanine green angiography, both clinical entities show choroidal vascular dilatation and hyperpermeability, leading presumably to choroidal thickening. However, we have recently reported laser speckle flowgraphy (LSFG) can distinguish these two disorders in regard to choroidal circulation changes. On LSFG, VKH and CSC showed opposite direction of changes in blood flow velocity, i.e., sequential increase and decrease, respectively, with regression of disease activity. These results may be reflected by the different pathogenesis of the two diseases. VKH at the acute stage has an inflammatory circulation disturbance in the thickened choroid with leukocyte adhesion to inner walls of vessels and massive infiltration into the stroma. In contrast, CSC at the acute stage has an increased hydrostatic pressure in the thickened choroid hyperperfused due to adrenergic vascular dysregulation. We have so far confirmed similar trends in several other clinical entities, such as serpiginous choroiditis and punctate inner choroidopathy as inflammatory diseases and hypertensive choroidopathy with non-inflammatory etiology. In this presentation, choroidal circulatory changes in inflammatory and non-inflammatory diseases with choroidal thickening will be highlighted and contrasted using LSFG.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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laser speckle flowgraphy
mean blur rate
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Tetsuya Sugiyama
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Photonics 2014, 1(3), 220-234; doi:
Basic Technology and Clinical Applications of the Updated Model of Laser Speckle Flowgraphy to Ocular Diseases
Nakano Eye Clinic of Kyoto Medical Co-operative, 2, Jurakumawari-Higashimachi, Nakagyo-ku, Kyoto 604-8404, Japan
Received: 20 July 2014 / Revised: 7 August 2014 / Accepted: 7 August 2014 / Published: 12 August 2014
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Abstract Laser speckle flowgraphy (LSFG) allows for quantitative estimation of
blood flow in the optic nerve head (ONH), choroid and retina, utilizing the laser speckle phenomenon. The basic technology and clinical applications of LSFG-NAVI, the updated model of LSFG, are summarized in this review. For developing a commercial version of LSFG, the special area sensor was replaced by the ordinary charge-coupled device camera. In LSFG-NAVI, the mean blur rate (MBR) has been introduced as a new parameter. Compared to the original LSFG model, LSFG-NAVI demonstrates a better spatial resolution of the blood flow map of human ocular fundus. The observation area is 24 times larger than the original system. The analysis software can separately calculate MBRs in the
blood vessels and tissues (capillaries) of an entire ONH and the measurements have good reproducibility. The absolute values of MBR in the ONH have been shown to linearly correlate with the capillary blood flow. The Analysis of MBR pulse waveform provides parameters including skew, blowout score, blowout time, rising and falling rates, flow acceleration index, acceleration time index, and resistivity index for comparing different eyes. Recently, there have been an increasing number of reports on the clinical applications of LSFG-NAVI to ocular diseases, including glaucoma, retinal and choroidal diseases.
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MDPI and ACS Style
Sugiyama, T.
Basic Technology and Clinical Applications of the Updated Model of Laser Speckle Flowgraphy to Ocular Diseases. Photonics 2014, 1, 220-234.
Sugiyama T.
Basic Technology and Clinical Applications of the Updated Model of Laser Speckle Flowgraphy to Ocular Diseases. Photonics. ):220-234.
Chicago/Turabian Style
Sugiyama, Tetsuya.
2014. "Basic Technology and Clinical Applications of the Updated Model of Laser Speckle Flowgraphy to Ocular Diseases." Photonics 1, no. 3: 220-234.
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