The electrolarynx as a communication tool for mechanically ventilated critically ill patients: a prospective feasibility study
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The electrolarynx as a communication tool for mechanically ventilated critically ill patients: a prospective feasibility studyKoji SatoMasaki OkajimaTakumi TaniguchiLetterDOI:
10.-016-4389-1Cite this article as: Sato, K., Okajima, M. & Taniguchi, T. Intensive Care Med (99. doi:10.-016-4389-1
1.Rotondi AJ, Chelluri L, Sirio C, Mendelsohn A, Schulz R, Belle S, Im K, Donahoe M, Pinsky MR (2002) Patients’ recollections of stressful experiences while receiving prolonged mechanical ventilation in an intensive care unit. Crit Care Med 30:746–7522.Adler JJ, Zeides J (1986) Evaluation of the electrolarynx in the short-term hospital setting. Chest 89:407–4093.Girbes AR, Elbers PW (2014) Speech in an orally intubated patient. N Engl J Med 370:4.Tuinman PR, Ten Hoorn S, Aalders YJ, Elbers PW, Girbes AR (2015) The electrolarynx improves communication in a selected group of mechanically ventilated critically ill patients: a feasibility study. Intensive Care Med 41:547–5485.Liu H, Ng ML (2007) Electrolarynx in voice rehabilitation. Auris Nasus Larynx 34:327–332Koji Sato1Masaki Okajima1Takumi Taniguchi121.Intensive Care UnitKanazawa University HospitalKanazawaJapan2.Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medical SciencesKanazawa UniversityKanazawaJapan
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We use cookies to improve your experience with our site.Helical tomotherapy-based craniospinal irradiation: mature outcomes of a prospective feasibility study
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Helical tomotherapy-based craniospinal irradiation: mature outcomes of a prospective feasibility studyTejpal GuptaBhooshan ZadeMahesh UpasaniZubin MasterReena PhurailatpamPurna KurkureHari MenonGodajayant SastriRakesh JalaliOriginal ResearchDOI:
10.-015-0235-2Cite this article as: Gupta, T., Zade, B., Upasani, M. et al. J Radiat Oncol (1. doi:10.-015-0235-2
The objective of the study was to report mature outcomes in patients treated on a prospective feasibility study of helical tomotherapy-based craniospinal irradiation.Patients needing craniospinal irradiation were accrued, treated, and followed up longitudinally for survival and toxicity on an institutional review board-approved study.Twenty patients (median age of 15 years) constituted the study cohort. Tomotherapy-based craniospinal irradiation was well tolerated with self-limiting and reversible acute toxicity. Four (20 %) patients needed growth factor or platelet support during craniospinal irradiation. Significant late neuro-toxicity was seen in only one (5 %) patient. None of the patients developed symptomatic radiation pneumonitis or second new malignancy. At a median follow-up of 62 months (inter-quartile range 24–71 months), the 5-year progression-free survival and overall survival for the entire cohort was 50 and 55 %, respectively. Outcomes within the cohort
patients with favorable biology disease had good outcomes while patients with high-risk, metastatic, or recurrent disease fared poorly reflecting inherently aggressive biology.Helical tomotherapy is an ideal platform for planning, verification, and delivery of supine craniospinal irradiation in clinical practice resulting in moderate, self-limiting, reversible acute toxicity and modest delayed toxicity. Patterns of failure and survival outcomes are largely dependent upon disease biology and are not any different compared to conventional techniques.BiologyCraniospinal irradiationSurvivalTomotherapyToxicity1.Samkari A, Hwang E, Packer RJ (2012) Medulloblastoma/Primitive neuroectodermal tumor and germ cell tumors: the uncommon but potentially curable primary brain tumors. Hematol Oncol Clin North Am 26(4):881–895. doi:
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15.Penagaricano JA, Papanikolaou N, Yan Y, Youssef E, Ratanatharathorn V (2005) Feasibility of cranio-spinal axis radiation with the Hi-Art tomotherapy system. Radiother Oncol: J Euro Soc Therapeutic Radiology Oncol 76(1):72–78. doi:
16.Bedford JL, Lee YK, Saran FH, Warrington AP (2012) Helical volumetric modulated arc therapy for treatment of craniospinal axis. Int J Radiat Oncol Biol Phys 83(3):. doi:
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Tejpal Gupta1Bhooshan Zade1Mahesh Upasani1Zubin Master2Reena Phurailatpam2Purna Kurkure3Hari Menon4Godajayant Sastri1Rakesh Jalali11.Department of Radiation OncologyACTREC/TMH, Tata Memorial CentreKhargharIndia2.Department of Medical PhysicsACTREC/TMH, Tata Memorial CentreParelIndia3.Department of Pediatric OncologyACTREC/TMH, Tata Memorial CentreParelIndia4.Department of Medical OncologyACTREC/TMH, Tata Memorial CentreParelIndia
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We use cookies to improve your experience with our site.A prospective feasibility and safety study of laparoscopy-assisted distal gastrectomy for... - Abstract - Europe PMC
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Takaki Yoshikawa
Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1-1-2 Nakao, Asahi-ku, Yokohama, 241-0815, Japan. yoshikawat@kcch.jp
Haruhiko Cho
Yasushi Rino
Yuji Yamamoto
Masayuki Kimura
Tetsu Fukunaga
Shinichi Hasegawa
Takanobu Yamada
Toru Aoyama
Akira Tsuburaya
Department of Gastrointestinal Surgery, Kanagawa Cancer Center, 1-1-2 Nakao, Asahi-ku, Yokohama, 241-0815, Japan. yoshikawat@kcch.jp
[):126-132]
Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't
10.-012-0157-2
The aim of this prospective study was to evaluate the feasibility and safety of laparoscopy-assisted distal gastrectomy (LADG) initiated by surgeons with much experience of open gastrectomy and laparoscopic surgery.Three surgeons who each had experience with more than 300 cases of open gastrectomy, more than 100 cases of laparoscopic cholecystectomy, more than 5 cases of laparoscopic colectomy, and more than 5 cases of laparoscopic partial gastrectomy were nominated as LADG operators. All three operators received training for LADG with study materials including videotapes, a box simulator, and an animal laboratory, with lectures and assistance from LADG instructors who each had experience of more than 50 LADG operations. Then the nominated LADG operators performed LADG with the instructors, in which their skills were evaluated and certified. Thereafter, they performed LADG without assistance from the instructors. The target of this study was clinical stage I gastric cancer that was resectable by distal gastrectomy. D1 + alpha, D1 + beta, or D2 dissection was performed laparoscopically. Basically reconstruction was done extracorporeally with a Billroth-I gastroduodenostomy. An extramural review board checked the surgical quality of the operations performed by the three surgeons. The primary endpoint was morbidity and mortality.A total of 193 patients were enrolled in this study between August 2004 and July 2009. The median blood loss was 35 ml and the median operation time was 250 min. Conversion to open surgery was seen in 6 4 due to bleeding and 2 due to advanced disease. Overall morbidity was 1.6 %, including grade 2 anastomotic leakage in 0.5 % and grade 2 pancreatic fistula in 0.5 %. No mortality was observed. The number of cases required until the LADG operators acted as LADG surgeons without an instructor was 3 for each of the three surgeons. When comparing the data between that in the training period (n = 9) and the operators' data (n = 174), the median operation time was significantly longer in the training period (355 min) than in the latter period (247.5 min) (p = 0.015). Median blood loss was also greater in the training period (150 ml) than the latter period (32.5 ml), but the difference did not reach statistical significance (p = 0.084). During the training period, no patient developed any complications of & grade 2.These results suggested that LADG could be initiated and performed feasibly and safely if surgeons with much experience of open gastrectomy and laparoscopic surgery received adequate training for LADG.
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