Reactive amyloidosis complicated by end-stage renal disease 28 years after liquid silicone injection in the buttocks -- d'Ythurbide
et al. 2012 -- BMJ Case Reports
BMJ Case Reports: publishing, sharing and learning through experience
BMJ Case Reports
doi:10.1136/bcr-
Unexpected outcome (positive or negative) including adverse drug reactions
1Department of Urgences Néphrologiques et Transplantation Rénale, APHP, H?pital Tenon, Paris, France
2Department of Nuclear Medicine, APHP, H?pital Tenon, Paris, France
3Department of Pathology, APHP, H?pital Tenon, Paris, France
4Université Pierre et Marie Curie, Paris 6, France
Correspondence to Professor Alexandre Hertig, alexandre.hertig{at}tnn.aphp.fr
Silicone ganulomas usually arise from the rupture of silicone implants. Until the 1980s, however, underground care providers
used to inject liquid and unapproved silicone directly into human tissues, in the absence of a containing capsule. We report
here the case of a man who ultimately developed end-stage renal disease (ESRD) because of a chronic glomerulosclerosis that
was attributed to a glomerular AA amyloidosis diagnosed 28 years after a buttock injection of liquid silicone. To our knowledge,
this is the first case of a silicone-induced AA amyloidosis irreversibly affecting the kidneys, and leading to ESRD. An interleukin
1 receptor antagonist was started to prevent the extension of amyloidosis, but to no avail as far as the kidneys are concerned.
We want to draw the attention of health professionals about the risk of developing AA amyloidosis secondary to a long-lasting
inflammation induced by silicone leakage, after a long latency period.
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