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题名: 纳米金结合聚噻吩衍生物比色检测目标靶DNA的方法
专利国别: 中国
专利类型: 发明
中文摘要: 本发明涉及一种纳米金结合聚噻吩衍生物比色检测目标靶DNA的方法，包括：检测试剂(纳米金和聚噻吩衍生物)及探针的准备；目标靶序列的检测等。该发明基于聚噻吩衍生物与ssDNA/dDNA结合时使得DNA-纳米金溶液的稳定性发生变化而引起颜色改变产生信号级联放大的原理，通过颜色转变显示剂以及扩增标签的双重作用实现DNA的高灵敏快速检测，从而建立利用纳米金结合聚噻吩衍生物进行基因直接检测的分析平台。该方法操作简单，不需要特殊的仪器设备，具有特异、快速和高灵敏的特点，可望应用于临床检验医学及环境中靶目标DNA的诊断和
语种: 中文
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毛红菊;王树;郭青川;娄新徽;张宏莲;金庆辉;赵建龙,纳米金结合聚噻吩衍生物比色检测目标靶DNA的方法,.X,2010
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题名: DNA在纳米金标上的组装、杂交、检测与银增强
卷号: 19, 期号:9, 页码:879-882关键词:
通讯作者: 李景虹
中文摘要: 利用电化学方法进行DNA的杂交检测.将目标ss-DNA固定在玻碳电极表面,使其与纳米金标记的互补DNA发生杂化反应,通过银增强试剂(该种试剂可以使银在纳米金表面沉积,达到信号增强的效果)在纳米金上沉积银,形成银包金的核壳结构.在酸性介质中沉积的银被氧化释放,以离子状态存在于溶液中.用阳极溶出伏安法(ASV)检测银离子从而达到间接检测目标DNA的目的.测定结果表明,ss-DNA的浓度在100～1 000 pmol·L~(-1)范围内有非常好的线性关系,检测限为10 pmol·L~(-1).
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王美佳;纪小会;王连英;刘敏;刘艳梅;白玉白;李铁津;李景虹.DNA在纳米金标上的组装、杂交、检测与银增强,物理化学学报, ):879-882
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Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.&<meta name="DC.Description" xml:lang="cn" content="金纳米颗粒拥有独特的光学和电学性质, 被广泛地应用于分析检测、催化和生物医学等领域. 通过改变尺寸和形状能够可控地调节金纳米颗粒的等离子体共振吸收峰, 进而改变金纳米颗粒的光学和电学特性. 而在金纳米表面修饰DNA, 使金纳米颗粒具有DNA的特异性识别能力和可寻址能力, 则能够有效地扩展金纳米颗粒在纳米组装、环境监测、疾病诊断、药物运输和纳米颗粒合成方面的应用. 本文系统总结了不同大小金纳米颗粒的合成方法, 探讨如何在金纳米颗粒上快速修饰DNA, 研究了影响金纳米颗粒表面DNA的修饰密度、功能及稳定性的因素, 并描述了DNA功能化的金纳米颗粒在检测、组装、载药和纳米颗粒合成中的应用. 本文将进一步加深人们对DNA功能化金纳米颗粒的制备、性质及应用的了解, 为DNA功能化金纳米颗粒的研究提供指导."/>
<meta name="DC.Description" xml:lang="en" content="Gold nanoparticles have been widely applied to different natural sciences due to its unique optical and electrical properties. It is easy to control the size and shape of gold nanoparticles to adjust the absorption peak of gold nanoparticles and change the optical and electrical properties. When gold nanoparticles are functionalized with DNA, they are endowed with the recognition ability and addressability of DNA, and it further widens the applications of gold nanoparticles in nanoparticle assembly, environmental monitoring, disease diagnosis, drug delivery, and nanoparticle synthesis. First, this review systematically summarized the synthesis of gold nanoparticles with different sizes. Second, it discussed how to rapidly functionalize gold nanoparticles with DNA. Moreover, it studied the factors that affect the density, function, and stability of DNA on gold nanoparticle surface. Finally, it described the applications of gold nanoparticles in detection, nanoparticle assembly, drug delivery, and nanoparticle synthesis. This review would promote understanding of the preparations, properties, and applications of DNA functionalized gold nanoparticles, and would provide guidance for the research of DNA functionalized gold nanoparticles."/>
DNA功能化金纳米及其应用
中国科学 化学
: &&&&DOI: 10.-00161
DNA功能化金纳米及其应用
李久兴, 刘如迪, 张益聪, 祝冰青, 姚秀洁, 林晖, 周雷激, 朱志, 杨朝勇*
固体表面物理化学国家重点实验室; 谱学分析与仪器教育部重点实验室; 厦门大学化学化工学院, 厦门 361005
Application of DNA functionalized gold nanoparticles
Jiuxing Li, Rudi Liu, Yicong Zhang, Bingqing Zhu, Xiujie Yao, Hui Lin, Leiji Zhou, Zhi Zhu, Chaoyong Yang*
State Key Laboratory of Physical Chemistry of Solid S Key Laboratory of Spectrochemical Analysis & Instrumentation, Ministry of E College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
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