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对基因间相互作用的研究和基因调控网络预测
该文中我们先应用改进后的微分方程模型对基因调控网络进行了推测.以往的微分方程模型由于方程中的参数个数远远大于实际的时间点的个数的缘故,没能将微分方程应用于基因组水平的真实测量数据;而这种改进后的微分方程不是通过直接确定参数值,而是将多元回归分析应用于方程,从而由真实的芯片试验数据推测基因调控网络.在实施微分方程算法推测基因调控网络的过程中,我们发现这一模型对结果的表达不太令人满意,因而该文又研究了平滑响应表面(SRS)算法.SRS算法可用来分析基因表达数据,在基因组水平上描述促进子、抑制子和目标基因三联体.文中我们应用SRS算法处理芽孢酵母S.cerivisiae细胞周期过程中检测到的基因表达数据,并结合生物学实际校验推测了由某些可能对细胞周期具有非凡意义的基因所构成的局部基因调控网络图.此外,根据计算结果,有一些基因的生物活性现在还没有实验观测数据来明确鉴定,但它们的分值提示它们有可能值得特别的关注.此外,我们对原始SRS算法作了一定改进,并将改进后的算法应用到对基因RFA1、RFA2、RFA3的生物现象特征规律的分析中,通过同原始算法所得结果进行比较,得到了一些有意义的结论.
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万方数据知识服务平台--国家科技支撑计划资助项目（编号：2006BAH03B01）(C)北京万方数据股份有限公司
万方数据电子出版社如何查找基因之间相互作用的数据库?
Biomolecular Interaction Network Database (BIND) archives biomolecular interaction,reaction,complex and pathway information curated from published experimental research.A database of physical and genetic interactions curated from the primary literature.Graphical layouts of interactions can be generated in a variety of file formats using Osprey.Domain Interaction MAp (DIMA) aims at becoming a comprehensive resource for functional and physical interactions among conserved protein-domains.The scope of the resource comprises both experimental data and computational predictions.Currently,DIMA is based on a domain phylogenetic profiling method and domain-domain contacts found in crystal structures (iPFAM).Database of Interacting Proteins (DIP) catalogues experimentally determined interactions between proteins.It combines information from a variety of sources to create a single,consistent set of protein-protein interactions.The data stored within the DIP database are curated,both,manually by expert curators and also automatically using computational approaches.Human Protein Reference Database (HPRD) represents a centralized platform to visually depict and integrate information pertaining to domain architecture,post-translational modifications,interaction networks and disease association for each protein in the human proteome.All the information in HPRD has been manually extracted from the literature by expert biologists.InterDom is a database of putative interacting protein domains derived from multiple sources,ranging from domain fusions (Rosetta Stone),protein interactions (DIP and BIND),protein complexes (PDB),to scientific literature (MEDLINE).It focuses on providing supporting evidence for validating and annotating detected protein interactions and complexes based on putative protein domain interactions.Molecular INTeraction database (MINT) focuses on experimentally verified protein interactions mined from the scientific literature by expert curators.The Munich Information center for Protein Sequences (MIPS) has two protein-protein interaction resources:MPact representing yeast protein-protein interaction data which is very comprehensive and is often considered to be the g and the Mammalian Protein-Protein Interaction (MPPI) Database containing manually curated high-quality data collected from the scientific literature by expert curators.The Prolinks database is a collection of inference methods used to predict functional linkages between proteins.These methods include the phylogenetic profile method,the ge-ne cluster method,Rosetta Stone,and the gene neighbor method.Protein Structural Interactome MAP (PSIMAP) is a tool for viewing interactions among protein domains in terms of their structural families to analyze the large-scale patterns and evolution of interactomes among species.STRING is a database of known and predicted protein-protein interactions.The interactions include direct (physical) and indirect (functional) they are derived from four sources: high-th and previous knowledge from databases and the scientific literature.STRING quantitatively integrates interaction data from these sources for,currently,373 organisms,and transfers information between these organisms where applicable.STRING uses orthology information from the COG database.这是来自台湾National Chiao Tung University的在线服务,特别推荐一下.
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http://www.thebiogrid.org/
基因会相互作用吗
扫描下载二维码如何在PUBMED中查与某个基因相关的转录因子?(基因,转录因子,相互作用,基因相互作用) - DNA技术 - 生物秀
标题: 如何在PUBMED中查与某个基因相关的转录因子?(基因,转录因子,相互作用,基因相互作用)
摘要: [如何在PUBMED中查与某个基因相关的转录因子?(基因,转录因子,相互作用,基因相互作用)] 各位好,请问在PUBMED中怎样查询与某基因相互作用的转录因子,或者说,怎样查找与该基因有相互作用的其他基因?谢谢! 关键词:[基因 转录因子 基因相互作用 相互作用]……
各位好,请问在PUBMED中怎样查询与某基因相互作用的转录因子,或者说,怎样查找与该基因有相互作用的其他基因?谢谢!
回复请求帮助！！！谢谢
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浅谈基因间的相互作用――由3：1和9：3：3：1想到的
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&&基​因​是​控​制​性​状​的​基​本​单​位​,​基​因​的​分​离​与​自​由​组​合​定​律​也​是​遗​传​部​分​教​学​的​重​点​。​在​这​两​部​分​内​容​的​学​习​中​有​两​个​重​要​的​比​例​：​一​对​相​对​性​状​的​杂​合​子​自​交​后​代​性​状​分​离​比​为：;​两​对​性​状​的​杂​合​子​自​交​后​代​性​状​分​离​比​为：：：。​考​查​此​类​的​试​题​是​考​试​中​的​重​难​点​,​也​是​常​见​的​失​分​点​。​因​为​在​实​际​中​基​因​一​般​都​不​是​独​立​起​作​用​的​,​生​物​的​性​状​也​往​往​不​是​简​单​地​决​定​于​单​个​基​因​,​而​是​基​因​间
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