专题专栏----产品召回----医疗器械召回
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植物学名解释-种加词
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你可能喜欢Drosophila CAPS is an essential gene that regulates dense-core vesicle release and synaptic vesicle fusion.
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2001 Aug 16;31(3):421-37.Drosophila CAPS is an essential gene that regulates dense-core vesicle release and synaptic vesicle fusion.1, , , , , , , , .1Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA.AbstractCalcium-activated protein for secretion (CAPS) is proposed to play an essential role in Ca2+-regulated dense-core vesicle exocytosis in vertebrate neuroendocrine cells. Here we report the cloning, mutation, and characterization of the Drosophila ortholog (dCAPS). Null dCAPS mutants display locomotory deficits and complete embryonic lethality. The mutant NMJ reveals a 50% loss in evoked glutamatergic transmission, and an accumulation of synaptic vesicles at active zones. Importantly, dCAPS mutants display a highly specific 3-fold accumulation of dense-core vesicles in synaptic terminals, which was not observed in mutants that completely arrest synaptic vesicle exocytosis. Targeted transgenic CAPS expression in identified motoneurons fails to rescue dCAPS neurotransmission defects, demonstrating a cell nonautonomous role in synaptic vesicle fusion. We conclude that dCAPS is required for dense-core vesicle release and that a dCAPS-dependent mechanism modulates synaptic vesicle release at glutamatergic synapses.PMID:
[PubMed - indexed for MEDLINE]
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尼可刹米（Nikethamide ,Coramine ）， 用于中枢性呼吸及循环衰竭、麻醉药、其他中枢抑制药的中毒急救
【药品名称】 尼可刹米
【英文/拉丁名称】Nikethamide 　　【别名】可拉明，尼可拉明，二乙烟酰胺，烟酰乙胺，Carbamidal，Cormed，Tonocarble，Ventramine，Cardiamine，Corediol，Corvofon，Pinacoryl，Eucoran，Nikardin，Stimulin，Cordiamid，Coramine。 　　【分子式】C10H14ON2 　　【来源与标准】 尼可刹米为N,N-二乙基-3- 吡啶甲酰胺。含C10H14N2O 不得少于98.5％(g/g) 　　【制剂/规格】1、注射液：0.25g/ml、0.375g/1.5ml、0.5g/2ml。2、溶液：25%50ml、25%100ml。 　　【类别】中枢兴奋药。 　　【生产企业】北京市永康药业有限公司、江苏吴中实业股份有限公司苏州第六制药厂、安...
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